The ability of Estrumate to induce abortion decreases beyond the fifth month of gestation while the risk of dystocia and its consequences increases. The induced abortion is normally uncomplicated and the fetus and placenta are usually expelled about 4 to 5 days after the injection with the reproductive tract returning to normal soon after the abortion. Unwanted pregnancies can be safely and efficiently terminated from 1 week after mating until about 5 months of gestation. For abortion of beef cows, lactating dairy cows, and replacement beef and dairy heifers Treatment with Estrumate can restore normal ovarian activity by causing regression of the luteal cyst.ĥ. For treatment of luteal cysts in beef cows, lactating dairy cows, and replacement beef and dairy heifersĪ cow or heifer may be noncyclic due to the presence of a luteal cyst (a single, anovulatory follicle with a thickened wall which is accompanied by no external signs and by no changes in palpable consistency of the uterus). Normal cyclical activity usually follows.Ĥ. (Manual assistance may be necessary to remove the fetus from the vagina). Induction of luteolysis with Estrumate usually results in expulsion of the mummified fetus from the uterus. For treatment of mummified fetus in beef cows, lactating dairy cows, and replacement beef and dairy heifersĭeath of the conceptus during gestation may be followed by its degeneration and dehydration. After 14 days post-treatment, recovery rate of treated animals will not be different than that of untreated cattle.ģ. Induction of luteolysis with Estrumate usually results in evacuation of the uterus and a return to normal cyclical activity within 14 days after treatment. This condition, commonly referred to as pyometra, is characterized by a lack of cyclical estrous behavior and the presence of a persistent corpus luteum.

Under certain circumstances, this may progress into chronic endometritis with the uterus becoming distended with purulent matter. For treatment of pyometra or chronic endometritis in beef cows, lactating dairy cows, and replacement beef and dairy heifersĭamage to the reproductive tract at calving or postpartum retention of the placenta often leads to infection and inflammation of the uterus (endometritis). If estrous detection is not desirable or possible, treated animals may be inseminated twice at about 72 and 96 hours post-injection.Ģ. Treated cattle should be inseminated at the usual time following detection of estrus. Estrus is expected to occur 2 to 5 days following injection, at which time animals may be inseminated. For unobserved or non-detected estrus in beef cows, lactating dairy cows, and replacement beef and dairy heifersĬows and heifers which are not detected in estrus, although ovarian cyclicity continues, can be treated with Estrumate if a mature corpus luteum is present. Discard bottle after one stopper puncture with draw-off spike.ġ. Use only with automatic injection equipment or repeater syringe. Two mL of Estrumate (500 mcg cloprostenol) should be administered by INTRAMUSCULAR INJECTION using the specific dosage regimen for the indication.Ģ0 mL bottle size: Use within 28 days of first puncture.ġ00 mL bottle size: Use within 28 days of first puncture and puncture a maximum of 12 times. Pregnant animals may abort depending on the stage of gestation. In animals with prolonged luteal function (pyometra, mummified fetus, and luteal cysts), the induced luteolysis usually results in resolution of the condition and return to cyclicity. In normal, non-pregnant cycling animals, this effect on the life span of the corpus luteum usually results in estrus 2 to 5 days after treatment. 1.ğor unobserved or non-detected estrus in beef cows, lactating dairy cows, and replacement beef and dairy heifersĢ.ğor treatment of pyometra or chronic endometritis in beef cows, lactating dairy cows, and replacement beef and dairy heifersģ.ğor treatment of mummified fetus in beef cows, lactating dairy cows, and replacement beef and dairy heifersĤ.ğor treatment of luteal cysts in beef cows, lactating dairy cows, and replacement beef and dairy heifersĥ.ğor abortion of beef cows, lactating dairy cows, and replacement beef and dairy heifersĦ.ğor estrus synchronization in beef cows, lactating dairy cows, and replacement beef and dairy heifersħ.ğor use with Fertagyl ® (gonadorelin) to synchronize estrous cycles to allow for fixed time artificial insemination (FTAI) in lactating dairy cows.Įstrumate causes functional and morphological regression of the corpus luteum (luteolysis) in cattle.

Compendium of veterinary products